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Research Article Open Access

Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents

 

Manoj D. Shanti, Kaveri D. Shanti, Jyotsna Meshram, Manisha Raut, Kamlakar Nandekar

 

1G.H. Raisoni College of Engineering, Nagpur, Maharashtra 440016, India

2Department of Chemistry, RTM Nagpur University, Nagpur, Maharashtra 440033, India

3Rajiv Gandhi College of Engineering & Research, Nagpur, Maharashtra 441110, India

 

Adv. Mater. Proc., 2020, 5 (3), 20030406

DOI: 10.5185/amp.2020.030406

Publication Date (Web):04/07/2020

Copyright © IAAM-VBRI Press

Abstract


A series of new phenothiazine derivatives of sulfonamide dyes was designed, synthesized & evaluated for their potent anti-cancer activities. The compounds were designed on the basis of molecular docking studies. Firstly they were docked with three different anticancer target enzymes viz. topoisomerase-II, aromatase and CDK2 and on the basis of dock score the designed compounds were synthesized. All synthesized compounds were bio-evaluated for their in-vitro anti-cancer action which displayed adequate results in agreement with the outcome of docking study.

Keywords


Docking, topoisomerase-II, aromatase enzyme, CDK2, phenothiazine derivatives of sulfonamide, anticancer evaluation